SHP-2(Phospho-Tyr542) Rabbit Polyclonal Antibody from Bioassay Technology Laboratory

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth: differentiation: mitotic cycle: and oncogenic transformation. This PTP contains two tandem Src homology-2 domains: which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions: such as mitogenic activation: metabolic control: transcription regulation: and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia